|Other Names||Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, ALDH5A1, SSADH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1472a was selected from the N-term region of human ALDH5A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).|
|Tissue Location||Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta|
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Provided below are standard protocols that you may find useful for product applications.
ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This protein functions as a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties.
Knerr,I., J. Inherit. Metab. Dis. 30 (3), 279-294 (2007)Blasi,P., J. Mol. Evol. 63 (1), 54-68 (2006)Plomin,R., Mol. Psychiatry 9 (6), 582-586 (2004)
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