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ALDH5A1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P51649
Clone Names 70319191
Additional Information
Gene ID 7915
Other Names Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, ALDH5A1, SSADH
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1472b was selected from the C-term region of human ALDH5A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH5A1 (HGNC:408)
Synonyms SSADH
Function Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Cellular Location Mitochondrion.
Tissue Location Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta
Research Areas
Citations (0)
citation

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Background

ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This protein functions as a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties.

References

Knerr,I., J. Inherit. Metab. Dis. 30 (3), 279-294 (2007)Blasi,P., J. Mol. Evol. 63 (1), 54-68 (2006)Plomin,R., Mol. Psychiatry 9 (6), 582-586 (2004)

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$ 277.78
Cat# BP1472b
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