MORC4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8TE76 |
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Clone Names | 100416176 |
Gene ID | 79710 |
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Other Names | MORC family CW-type zinc finger protein 4, Zinc finger CW-type coiled-coil domain protein 2, MORC4, ZCWCC2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MORC4 |
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Synonyms | ZCW4, ZCWCC2 |
Function | Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034). |
Cellular Location | Nucleus. |
Tissue Location | Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas |
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Provided below are standard protocols that you may find useful for product applications.
Background
In human, the four current members of the microrchidia(morc) gene family share an N-terminal ATPase-like ATP-bindingregion and a CW four-cysteine zinc-finger motif. The proteinencoded by this gene also has a nuclear matrix binding domain and atwo-stranded coiled-coil motif near its C-terminus. This gene iswidely expressed at low levels in normal tissues and has elevatedexpression in placenta and testis. Alternative splicing results inmultiple transcript variants encoding distinct proteins. [providedby RefSeq].
References
Liggins, A.P., et al. Br. J. Haematol. 138(4):479-486(2007)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Perry, J., et al. Trends Biochem. Sci. 28(11):576-580(2003)
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