|Other Names||NudC domain-containing protein 1, Chronic myelogenous leukemia tumor antigen 66, Tumor antigen CML66, NUDCD1 (HGNC:24306)|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus. Isoform 3: Cytoplasm. Nucleus.|
|Tissue Location||Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells|
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NUDCD1 (CML66) contains 1 CS domain. It may play an oncogenic role in ways of favoring tumor cells proliferation, invasion and metastasis-associated with multiple pathways.NUDCD1 is expressed in leukemias and a variety of solid tumor cell lines. Northern blot analysis showed expression in normal tissues restricted to testis and heart, and no expression was found in hematopoietic tissues.
Wang, Q., et al. Cancer Lett. 269(1):127-138(2008)Jin, S., et al. Cancer Sci. 99(8):1670-1678(2008)Yan, Y., et al. J. Immunol. 172(1):651-660(2004)Yang, X.F., et al. Proc. Natl. Acad. Sci. U.S.A. 98(13):7492-7497(2001)
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