|Other Names||DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II subunit B, RNA polymerase II subunit 2, RNA polymerase II subunit B2, POLR2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the second largest subunit of RNApolymerase II, the polymerase responsible for synthesizingmessenger RNA in eukaryotes. This subunit, in combination with atleast two other polymerase subunits, forms a structure within thepolymerase that maintains contact in the active site of the enzymebetween the DNA template and the newly synthesized RNA. [providedby RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)Tu, S., et al. Nat. Struct. Mol. Biol. 15(4):419-421(2008)Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)Yamaguchi, Y., et al. Genes Cells 12(7):863-875(2007)
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