|Other Names||P2Y purinoceptor 2, P2Y2, ATP receptor, P2U purinoceptor 1, P2U1, P2U receptor 1, Purinergic receptor, P2RY2, P2RU1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Spleen, testis, kidney, liver, lung, heart and brain|
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The product of this gene belongs to the family ofG-protein coupled receptors. This family has several receptorsubtypes with different pharmacological selectivity, which overlapsin some cases, for various adenosine and uridine nucleotides. Thisreceptor is responsive to both adenosine and uridine nucleotides.It may participate in control of the cell cycle of endometrialcarcinoma cells. Three transcript variants encoding the sameprotein have been identified for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Boucher, I., et al. Am. J. Physiol., Cell Physiol. 299 (2), C411-C421 (2010) :Ratchford, A.M., et al. J. Biol. Chem. 285(10):7545-7555(2010)Taboubi, S., et al. Mol. Biol. Cell 21(6):946-955(2010)Vazquez-Cuevas, F.G., et al. Reprod. Biol. Endocrinol. 8, 88 (2010) :
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