|Other Names||Lamina-associated polypeptide 2, isoform alpha, Thymopoietin isoform alpha, TP alpha, Thymopoietin-related peptide isoform alpha, TPRP isoform alpha, Thymopoietin, TP, Splenin, Thymopentin, TP5, TMPO, LAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.|
|Cellular Location||Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus|
|Tissue Location||Expressed in many tissues. Most abundant in adult thymus and fetal liver|
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The protein encoded by this gene resides in the nucleusand may play a role in the assembly of the nuclear lamina, and thushelp maintain the structural organization of the nuclear envelope.It may function as a receptor for the attachment of lamin filamentsto the inner nuclear membrane. Mutations in this gene areassociated with dilated cardiomyopathy. Alternatively splicedtranscript variants encoding different isoforms have been noted forthis gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Craig, D.W., et al. Diabet. Med. 26(11):1090-1098(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Shaklai, S., et al. Eur. J. Cell Biol. 87(5):267-278(2008)
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