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MCM6 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14566
Clone Names 100525202
Peptide ID 100525202
Additional Information
Gene ID 4175
Other Names DNA replication licensing factor MCM6, p105MCM, MCM6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM6
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Cellular Location Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase
Research Areas
Citations (0)

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The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by the MCM proteins is a keycomponent of the pre-replication complex (pre_RC) and may beinvolved in the formation of replication forks and in therecruitment of other DNA replication related proteins. The MCMcomplex consisting of this protein and MCM2, 4 and 7 proteinspossesses DNA helicase activity, and may act as a DNA unwindingenzyme. The phosphorylation of the complex by CDC2 kinase reducesthe helicase activity, suggesting a role in the regulation of DNAreplication.


Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1341-1348(2010)Wei, Z., et al. J. Biol. Chem. 285(17):12469-12473(2010)Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 80.00
Cat# BP14743a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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