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MCM6 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q14566
Clone Names 100525202
Additional Information
Gene ID 4175
Other Names DNA replication licensing factor MCM6, p105MCM, MCM6
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM6 (HGNC:6949)
Function Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:16899510, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425).
Cellular Location Nucleus. Chromosome. Note=Binds to chromatin during G1 and detaches from it during S phase.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by the MCM proteins is a keycomponent of the pre-replication complex (pre_RC) and may beinvolved in the formation of replication forks and in therecruitment of other DNA replication related proteins. The MCMcomplex consisting of this protein and MCM2, 4 and 7 proteinspossesses DNA helicase activity, and may act as a DNA unwindingenzyme. The phosphorylation of the complex by CDC2 kinase reducesthe helicase activity, suggesting a role in the regulation of DNAreplication.

References

Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1341-1348(2010)Wei, Z., et al. J. Biol. Chem. 285(17):12469-12473(2010)Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 277.78
Cat# BP14743a
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