|Other Names||DNA replication licensing factor MCM6, p105MCM, MCM6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|
|Cellular Location||Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase|
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The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by the MCM proteins is a keycomponent of the pre-replication complex (pre_RC) and may beinvolved in the formation of replication forks and in therecruitment of other DNA replication related proteins. The MCMcomplex consisting of this protein and MCM2, 4 and 7 proteinspossesses DNA helicase activity, and may act as a DNA unwindingenzyme. The phosphorylation of the complex by CDC2 kinase reducesthe helicase activity, suggesting a role in the regulation of DNAreplication.
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Timpson, N.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1341-1348(2010)Wei, Z., et al. J. Biol. Chem. 285(17):12469-12473(2010)Upton, J., et al. N. Z. Med. J. 123 (1308), 123 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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