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CD70 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P32970 |
|---|---|
| Clone Names | 100525205 |
| Gene ID | 970 |
|---|---|
| Other Names | CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CD70 |
|---|---|
| Synonyms | CD27L, CD27LG, TNFSF7 |
| Function | Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. |
| Cellular Location | Membrane; Single- pass type II membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thiscytokine is a ligand for TNFRSF27/CD27. It is a surface antigen onactivated, but not on resting, T and B lymphocytes. It inducesproliferation of costimulated T cells, enhances the generation ofcytolytic T cells, and contributes to T cell activation. Thiscytokine is also reported to play a role in regulating B-cellactivation, cytotoxic function of natural killer cells, andimmunoglobulin sythesis.
References
Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010)Shaw, J., et al. Blood 115(15):3051-3057(2010)Yu, S.E., et al. Mol. Cells 29(2):217-221(2010)Kozlowska, A., et al. J. Rheumatol. 37(1):53-59(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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