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GRAP2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75791 |
|---|---|
| Clone Names | 100525208 |
| Gene ID | 9402 |
|---|---|
| Other Names | GRB2-related adapter protein 2, Adapter protein GRID, GRB-2-like protein, GRB2L, GRBLG, GRBX, Grf40 adapter protein, Grf-40, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, P38, Protein GADS, SH3-SH2-SH3 adapter Mona, GRAP2, GADS, GRB2L, GRID |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GRAP2 |
|---|---|
| Synonyms | GADS, GRB2L, GRID |
| Function | Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. |
| Cellular Location | Nucleus. Cytoplasm. Endosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the GRB2/Sem5/Drk family.This member is an adaptor-like protein involved inleukocyte-specific protein-tyrosine kinase signaling. Like itsrelated family member, GRB2-related adaptor protein (GRAP), thisprotein contains an SH2 domain flanked by two SH3 domains. Thisprotein interacts with other proteins, such as GRB2-associatedbinding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2),through its SH3 domains. Transcript variants utilizing alternativepolyA sites exist.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Preisinger, C., et al. Cell. Signal. 22(5):848-856(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)Ludwig, L., et al. Cancer Lett. 275(2):194-197(2009)
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