|Other Names||Coilin, p80-coilin, COIL, CLN80|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.|
|Cellular Location||Nucleus. Nucleus, Cajal body|
|Tissue Location||Found in all the cell types examined.|
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The protein encoded by this gene is an integral componentof Cajal bodies (also called coiled bodies). Cajal bodies arenuclear suborganelles of varying number and composition that areinvolved in the post-transcriptional modification of small nuclearand small nucleolar RNAs. The N-terminus of the coilin proteindirects its self-oligomerization while the C-terminus influencesthe number of nuclear bodies assembled per cell. Differentialmethylation and phosphorylation of coilin likely influences itslocalization among nuclear bodies and the composition and assemblyof Cajal bodies. This gene has pseudogenes on chromosome 4 andchromosome 14.
Shanbhag, R., et al. FEBS Lett. 584(20):4351-4356(2010)Tapia, O., et al. Chromosoma 119(5):527-540(2010)Toyota, C.G., et al. Chromosoma 119(2):205-215(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Hearst, S.M., et al. J. Cell. Sci. 122 (PT 11), 1872-1881 (2009) :
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