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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Alkaline Phosphatase (ALPL) Antibody (N-term) Blocking peptide   

Alkaline Phosphatase (ALPL) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P05186
Clone Names 70716026
Peptide ID 70716026
Additional Information
Gene ID 249
Other Names Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney isozyme, ALPL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1474a was selected from the N-term region of human ALPL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function This isozyme may play a role in skeletal mineralization.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Research Areas
Citations (0)

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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The genes for the first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. This protein is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to a disorder known as hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.


Panuccio,V., Am. J. Kidney Dis. 50 (6), 1001-1008 (2007)Brun-Heath,I., Eur J Med Genet 50 (5), 367-378 (2007)So,P.P., J. Rheumatol. 34 (6), 1313-1322 (2007)

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$ 80.00
Cat# BP1474a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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