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PTGES3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15185
Clone Names 100525220
Peptide ID 100525220
Additional Information
Gene ID 10728
Other Names Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTGES3
Synonyms P23, TEBP
Function Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.

References

Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)Lee, J.H., et al. Cancer Lett. 290(1):76-86(2010)Chadli, A., et al. J. Biol. Chem. 285(6):4224-4231(2010)Woo, S.H., et al. J. Biol. Chem. 284(45):30871-30880(2009)Mattila, S., et al. Neuropathology 29(2):156-165(2009)

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$ 80.00
Cat# BP14751c
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