|Other Names||Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).|
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Provided below are standard protocols that you may find useful for product applications.
Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.
Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)Lee, J.H., et al. Cancer Lett. 290(1):76-86(2010)Chadli, A., et al. J. Biol. Chem. 285(6):4224-4231(2010)Woo, S.H., et al. J. Biol. Chem. 284(45):30871-30880(2009)Mattila, S., et al. Neuropathology 29(2):156-165(2009)
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