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UBE2D2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P62837
Clone Names 100525222
Peptide ID 100525222
Additional Information
Gene ID 7322
Other Names Ubiquitin-conjugating enzyme E2 D2, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase D2, p53-regulated ubiquitin-conjugating enzyme 1, UBE2D2, PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2D2
Synonyms PUBC1, UBC4, UBC5B, UBCH4, UBCH5B
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. This enzyme functions in theubiquitination of the tumor-suppressor protein p53, which isinduced by an E3 ubiquitin-protein ligase. Two alternativelyspliced transcript variants have been found for this gene and theyencode distinct isoforms.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Wu, K., et al. Mol. Cell 37(6):784-796(2010)Vina-Vilaseca, A., et al. J. Biol. Chem. 285(10):7645-7656(2010)Sakata, E., et al. Structure 18(1):138-147(2010)Kamadurai, H.B., et al. Mol. Cell 36(6):1095-1102(2009)

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$ 80.00
Cat# BP14752b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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