|Other Names||Neuroglobin, NGB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.|
|Cellular Location||Perikaryon. Cytoplasm. Mitochondrion|
|Tissue Location||Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.|
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This gene encodes an oxygen-binding protein that isdistantly related to members of the globin gene family. It ishighly conserved among other vertebrates. It is expressed in thecentral and peripheral nervous system where it may be involved inincreasing oxygen availability and providing protection underhypoxic/ischemic conditions.
Li, R.C., et al. J. Cereb. Blood Flow Metab. 30(11):1874-1882(2010)Astudillo, L., et al. Biophys. J. 99 (2), L16-L18 (2010) :Chuang, P.Y., et al. J. Neurotrauma 27(6):999-1006(2010)Mu, J., et al. Spectrochim Acta A Mol Biomol Spectrosc 75(5):1600-1604(2010)Raychaudhuri, S., et al. Apoptosis 15(4):401-411(2010)
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