|Other Names||Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus|
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A number of specific carrier proteins for members of thevitamin A family have been discovered. Cellular retinoic acidbinding proteins (CRABP) are low molecular weight proteins whoseprecise function remains unknown. The inducibility of the CRABP2gene suggests that this isoform is important in retinoicacid-mediated regulation of human skin growth and differentiation.It has been postulated that the CRABP2 gene is transcriptionallyregulated by a newly synthesized regulatory protein. [provided byRefSeq].
Sola, R., et al. Atherosclerosis 211(2):630-637(2010)Manolescu, D.C., et al. Pediatr. Res. 67(6):598-602(2010)Calmon, M.F., et al. Neoplasia 11(12):1329-1339(2009)Corlazzoli, F., et al. PLoS ONE 4 (1), E4305 (2009) :Gupta, A., et al. Exp. Cell Res. 314(20):3663-3668(2008)
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