|Other Names||Signal-transducing adaptor protein 1, STAP-1, BCR downstream-signaling protein 1, Docking protein BRDG1, Stem cell adaptor protein 1, STAP1, BRDG1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1475a was selected from the N-term region of human STAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion|
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Provided below are standard protocols that you may find useful for product applications.
STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
Ma,J., Atherosclerosis 191 (1), 63-72 (2007)Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)Gstaiger,M., Science 302 (5648), 1208-1212 (2003)Minoguchi,M., J. Biol. Chem. 278 (13), 11182-11189 (2003)
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