BRDG 1 Antibody (N-term F56) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9ULZ2 |
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Clone Names | 70319176 |
Gene ID | 26228 |
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Other Names | Signal-transducing adaptor protein 1, STAP-1, BCR downstream-signaling protein 1, Docking protein BRDG1, Stem cell adaptor protein 1, STAP1, BRDG1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1475a was selected from the N-term region of human STAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | STAP1 |
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Synonyms | BRDG1 |
Function | In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. |
Cellular Location | Nucleus. Cytoplasm. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
References
Ma,J., Atherosclerosis 191 (1), 63-72 (2007)Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)Gstaiger,M., Science 302 (5648), 1208-1212 (2003)Minoguchi,M., J. Biol. Chem. 278 (13), 11182-11189 (2003)
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