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HTATIP2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BUP3
Clone Names 100525250
Peptide ID 100525250
Additional Information
Gene ID 10553
Other Names Oxidoreductase HTATIP2, 111-, 30 kDa HIV-1 TAT-interacting protein, HIV-1 TAT-interactive protein 2, HTATIP2 (HGNC:16637)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTATIP2 (HGNC:16637)
Function Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Cellular Location Cytoplasm. Nucleus envelope
Tissue Location Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas
Research Areas
Citations (0)

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Background

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

References

Chen, X., et al. Dig. Dis. Sci. 55(8):2219-2226(2010)Fong, S., et al. BMC Cell Biol. 11, 23 (2010) :Nakahara, J., et al. Expert Opin. Ther. Targets 13(12):1375-1386(2009)Tong, X., et al. Am. J. Pathol. 174(5):1931-1939(2009)Nakahara, J., et al. J. Clin. Invest. 119(1):169-181(2009)

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$ 80.00
Cat# BP14762a
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