|Other Names||Calcium-dependent phospholipase A2, Group V phospholipase A2, PLA2-10, Phosphatidylcholine 2-acylhydrolase 5, PLA2G5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.|
|Tissue Location||Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level).|
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This gene is a member of the secretory phospholipase A2family. It is located in a tightly-linked cluster of secretoryphospholipase A2 genes on chromosome 1. The encoded enzymecatalyzes the hydrolysis of membrane phospholipids to generatelysophospholipids and free fatty acids including arachidonic acid.It preferentially hydrolyzes linoleoyl-containingphosphatidylcholine substrates. Secretion of this enzyme is thoughtto induce inflammatory responses in neighboring cells.Alternatively spliced transcript variants have been found, buttheir full-length nature has not been determined. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Wootton, P.T., et al. Hum. Mol. Genet. 16(12):1437-1444(2007)de Beer, F.C., et al. Arterioscler. Thromb. Vasc. Biol. 26(7):1421-1422(2006)
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