|Other Names||U1 small nuclear ribonucleoprotein A, U1 snRNP A, U1-A, U1A, SNRPA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene associates with stem loopII of the U1 small nuclear ribonucleoprotein, which binds the 5'splice site of precursor mRNAs and is required for splicing. Theencoded protein autoregulates itself by polyadenylation inhibitionof its own pre-mRNA via dimerization and has been implicated in thecoupling of splicing and polyadenylation.
Guan, F., et al. RNA 13(12):2129-2140(2007)Hall-Pogar, T., et al. RNA 13(7):1103-1115(2007)Shajani, Z., et al. J. Mol. Biol. 349(4):699-715(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Jessen, T.H., et al. EMBO J. 10(11):3447-3456(1991)
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