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COBRA1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WX92 |
|---|---|
| Clone Names | 100525257 |
| Gene ID | 25920 |
|---|---|
| Other Names | Negative elongation factor B, NELF-B, Cofactor of BRCA1, NELFB, COBRA1, KIAA1182 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NELFB |
|---|---|
| Synonyms | COBRA1 {ECO:0000303|PubMed:11739404}, KI |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). May be able to induce chromatin unfolding (PubMed:11739404). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism- related genes (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
NELFB is a subunit of negative elongation factor (NELF),which also includes NELFA (WHSC2; MIM 606026), either NELFC orNELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF actswith DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4(SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to causetranscriptional pausing of RNA polymerase II (see MIM 180660)(Narita et al., 2003 [PubMed 12612062]).
References
Sun, J., et al. J. Cell. Biochem. 103(6):1798-1807(2008)Sun, J., et al. J. Steroid Biochem. Mol. Biol. 107 (3-5), 131-139 (2007) :Wu, C., et al. Proteomics 7(11):1775-1785(2007)Narita, T., et al. Mol. Cell 26(3):349-365(2007)Aiyar, S.E., et al. Int. J. Biol. Sci. 3(7):486-492(2007)
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