|Other Names||Transcriptional adapter 3, ADA3 homolog, hADA3, STAF54, Transcriptional adapter 3-like, ADA3-like protein, TADA3, ADA3, TADA3L|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.|
|Tissue Location||Ubiquitously expressed.|
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Many DNA-binding transcriptional activator proteinsenhance the initiation rate of RNA polymerase II-mediated genetranscription by interacting functionally with the generaltranscription machinery bound at the basal promoter. Adaptorproteins are usually required for this activation, possibly toacetylate and destabilize nucleosomes, thereby relieving chromatinconstraints at the promoter. The protein encoded by this gene is atranscriptional activator adaptor and has been found to be part ofthe PCAF histone acetylase complex. In addition, it associates withthe tumor suppressor protein p53 and is required for full activityof p53 and p53-mediated apoptosis. At least four alternativelyspliced variants have been found for this gene, but the full-lengthnature of some variants has not been determined. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Li, C.W., et al. Nucleic Acids Res. 38(16):5291-5303(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hu, Y., et al. Cancer Invest. 27(3):298-306(2009)Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)
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