|Other Names||Septin-5, Cell division control-related protein 1, CDCrel-1, Peanut-like protein 1, SEPT5, PNUTL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules|
|Tissue Location||Expressed at high levels in the CNS, as well as in heart and platelets (at protein level)|
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This gene is a member of the septin gene family ofnucleotide binding proteins, originally described in yeast as celldivision cycle regulatory proteins. Septins are highly conserved inyeast, Drosophila, and mouse and appear to regulate cytoskeletalorganization. Disruption of septin function disturbs cytokinesisand results in large multinucleate or polyploid cells. This gene ismapped to 22q11, the region frequently deleted in DiGeorge andvelocardiofacial syndromes. A translocation involving the MLL geneand this gene has also been reported in patients with acute myeloidleukemia. Alternative splicing results in multiple transcriptvariants. The presence of a non-consensus polyA signal (AACAAT) inthis gene also results in read-through transcription into thedownstream neighboring gene (GP1BB; platelet glycoprotein Ib),whereby larger, non-coding transcripts are produced. [provided byRefSeq].
Jung, A.E., et al. Mol. Ther. 16(6):1048-1055(2008)Amin, N.D., et al. J. Neurosci. 28(14):3631-3643(2008)Xin, X., et al. J. Histochem. Cytochem. 55(11):1089-1094(2007)Blaser, S., et al. J. Pathol. 210(1):103-110(2006)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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