|Other Names||Hsp70-binding protein 1, HspBP1, Heat shock protein-binding protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 1, Hsp70-interacting protein 2, HSPBP1, HSPBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.|
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Provided below are standard protocols that you may find useful for product applications.
HSPBP1 inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Graner, M.W., et al. Cancer Sci. 100(10):1870-1879(2009)Evdonin, A., et al. Biol. Cell 101(6):351-360(2009)Souza, A.P., et al. Cell Stress Chaperones 14(3):301-310(2009)Howarth, J.L., et al. J. Neurochem. 108(4):945-951(2009)Snyers, L., et al. Biochem. Biophys. Res. Commun. 368(3):767-771(2008)
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