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HSPBP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NZL4 |
|---|---|
| Clone Names | 100525303 |
| Gene ID | 23640 |
|---|---|
| Other Names | Hsp70-binding protein 1, HspBP1, Heat shock protein-binding protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 1, Hsp70-interacting protein 2, HSPBP1, HSPBP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HSPBP1 (HGNC:24989) |
|---|---|
| Synonyms | HSPBP |
| Function | Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HSPBP1 inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
References
Graner, M.W., et al. Cancer Sci. 100(10):1870-1879(2009)Evdonin, A., et al. Biol. Cell 101(6):351-360(2009)Souza, A.P., et al. Cell Stress Chaperones 14(3):301-310(2009)Howarth, J.L., et al. J. Neurochem. 108(4):945-951(2009)Snyers, L., et al. Biochem. Biophys. Res. Commun. 368(3):767-771(2008)
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