|Other Names||Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, Insrr, Irr|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the islets as well as in pancreatic beta-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
Hanke, S., et al. Mol. Cell Proteomics 8(3):519-534(2009)Hoffman, B.G., et al. Genome Biol. 9 (6), R99 (2008) :Nef, S., et al. Nature 426(6964):291-295(2003)Kitamura, T., et al. Mol. Cell. Biol. 21(16):5624-5630(2001)Tsuji, T., et al. Exp. Anim. 50(4):359-360(2001)
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