CD106 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P19320 |
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Clone Names | 81020006 |
Gene ID | 7412 |
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Other Names | Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | VCAM1 |
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Function | Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Serves also as a quality- control checkpoint for entry into bone marrow by providing a 'don't- eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567). |
Cellular Location | [Vascular cell adhesion protein 1]: Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the Ig superfamily and encodes acell surface sialoglycoprotein expressed by cytokine-activatedendothelium. This type I membrane protein mediatesleukocyte-endothelial cell adhesion and signal transduction, andmay play a role in the development of artherosclerosis andrheumatoid arthritis. Two alternatively spliced transcriptsencoding different isoforms have been described for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Jin, C., et al. Coron. Artery Dis. 21(5):273-277(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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