|Other Names||Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue|
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This gene is a member of the Ig superfamily and encodes acell surface sialoglycoprotein expressed by cytokine-activatedendothelium. This type I membrane protein mediatesleukocyte-endothelial cell adhesion and signal transduction, andmay play a role in the development of artherosclerosis andrheumatoid arthritis. Two alternatively spliced transcriptsencoding different isoforms have been described for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Jin, C., et al. Coron. Artery Dis. 21(5):273-277(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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