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CD106 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P19320
Clone Names 81020006
Additional Information
Gene ID 7412
Other Names Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1, L1CAM
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VCAM1
Function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Serves also as a quality- control checkpoint for entry into bone marrow by providing a 'don't- eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567).
Cellular Location [Vascular cell adhesion protein 1]: Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue
Research Areas
Citations (0)
citation

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Background

This gene is a member of the Ig superfamily and encodes acell surface sialoglycoprotein expressed by cytokine-activatedendothelium. This type I membrane protein mediatesleukocyte-endothelial cell adhesion and signal transduction, andmay play a role in the development of artherosclerosis andrheumatoid arthritis. Two alternatively spliced transcriptsencoding different isoforms have been described for this gene.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)Jin, C., et al. Coron. Artery Dis. 21(5):273-277(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)

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$ 277.78
Cat# BP14788c
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