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A2M Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P01023
Clone Names 80722059
Peptide ID 80722059
Additional Information
Gene ID 2
Other Names Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name A2M
Synonyms CPAMD5
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Cellular Location Secreted.
Tissue Location Secreted in plasma.
Research Areas
Citations (0)

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Alpha-2-macroglobulin is a protease inhibitor and cytokinetransporter. It inhibits many proteases, including trypsin,thrombin and collagenase. A2M is implicated in Alzheimer disease(AD) due to its ability to mediate the clearance and degradation ofA-beta, the major component of beta-amyloid deposits. [provided byRefSeq].


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bruno, E., et al. Neurosci. Lett. 482(2):112-116(2010)Nalpas, B., et al. Gut 59(8):1120-1126(2010)Song, H., et al. Neurosci. Lett. 479(2):143-145(2010)Seriramalu, R., et al. Electrophoresis 31(14):2388-2395(2010)

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$ 80.00
Cat# BP14789a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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