|Other Names||Multiple coagulation factor deficiency protein 2, Neural stem cell-derived neuronal survival protein, MCFD2, SDNSF|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1478c was selected from the Center region of human MCFD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. MCFD2 interacts in a calcium-dependent manner with LMAN1. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency (F5F8D); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins.
Nyfeler,B., Traffic 7 (11), 1473-1481 (2006)Mohanty,D., Am. J. Hematol. 79 (4), 262-266 (2005)Zhang,B., J. Biol. Chem. 280 (27), 25881-25886 (2005)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.