MCFD2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NI22 |
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Clone Names | 70319170 |
Gene ID | 90411 |
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Other Names | Multiple coagulation factor deficiency protein 2, Neural stem cell-derived neuronal survival protein, MCFD2, SDNSF |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1478c was selected from the Center region of human MCFD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MCFD2 |
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Synonyms | SDNSF |
Function | The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors. |
Cellular Location | Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Golgi apparatus |
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Provided below are standard protocols that you may find useful for product applications.
Background
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. MCFD2 interacts in a calcium-dependent manner with LMAN1. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency (F5F8D); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D is an autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting proteins.
References
Nyfeler,B., Traffic 7 (11), 1473-1481 (2006)Mohanty,D., Am. J. Hematol. 79 (4), 262-266 (2005)Zhang,B., J. Biol. Chem. 280 (27), 25881-25886 (2005)
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