|Other Names||Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.|
|Tissue Location||Secreted in plasma.|
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Alpha-2-macroglobulin is a protease inhibitor and cytokinetransporter. It inhibits many proteases, including trypsin,thrombin and collagenase. A2M is implicated in Alzheimer disease(AD) due to its ability to mediate the clearance and degradation ofA-beta, the major component of beta-amyloid deposits. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bruno, E., et al. Neurosci. Lett. 482(2):112-116(2010)Nalpas, B., et al. Gut 59(8):1120-1126(2010)Song, H., et al. Neurosci. Lett. 479(2):143-145(2010)Seriramalu, R., et al. Electrophoresis 31(14):2388-2395(2010)
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