|Other Names||TATA-binding protein-associated factor 2N, 68 kDa TATA-binding protein-associated factor, TAF(II)68, TAFII68, RNA-binding protein 56, TAF15, RBP56, TAF2N|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm|
|Tissue Location||Ubiquitous. Observed in all fetal and adult tissues|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase II requiresthe activities of more than 70 polypeptides. The protein thatcoordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymeraseproperly, serves as the scaffold for assembly of the remainder ofthe transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and agroup of evolutionarily conserved proteins known as TBP-associatedfactors or TAFs. TAFs may participate in basal transcription, serveas coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly andtranscription initiation. This gene encodes a subunit of TFIIDpresent in a subset of TFIID complexes. Translocations involvingchromosome 17 and chromosome 9, where the gene for the nuclearreceptor CSMF is located, result in a gene fusion product that isan RNA binding protein associated with a subset of extraskeletalmyxoid chondrosarcomas. Two transcripts encoding different isoformshave been identified.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Schatz, N., et al. Cancer Res. 70(1):398-408(2010)Alves, J., et al. Biochem. Biophys. Res. Commun. 384(4):495-500(2009)Jobert, L., et al. EMBO Rep. 10(5):494-500(2009)Jobert, L., et al. Exp. Cell Res. 315(7):1273-1286(2009)
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