|Other Names||Transcription factor IIIB 90 kDa subunit, TFIIIB90, hTFIIIB90, B-related factor 1, BRF-1, hBRF, TAF3B2, TATA box-binding protein-associated factor, RNA polymerase III, subunit 2, BRF1, BRF, GTF3B, TAF3B2, TAF3C|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BRF, GTF3B, TAF3B2, TAF3C|
|Function||General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.|
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This gene encodes one of the three subunits of the RNApolymerase III transcription factor complex. This complex plays acentral role in transcription initiation by RNA polymerase III ongenes encoding tRNA, 5S rRNA, and other small structural RNAs. Thegene product belongs to the TF2B family. Two alternatively splicedvariants encoding different isoforms, that function at differentpromoters transcribed by RNA polymerase III, have been identified.Other transcript variants are possible, but their full-lengthnatures have not been completely characterized. [provided byRefSeq].
Haurie, V., et al. Proc. Natl. Acad. Sci. U.S.A. 107(9):4176-4181(2010)Maitra, S., et al. RNA 14(5):950-959(2008)Leal, J.F., et al. Oncogene 27(14):1961-1970(2008)Yoo, N.K., et al. Cell. Microbiol. 10(3):583-592(2008)Cabarcas, S., et al. BMC Mol. Biol. 9, 74 (2008) :
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