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WHSC2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H3P2
Clone Names 100430354
Peptide ID 100430354
Additional Information
Gene ID 7469
Other Names Negative elongation factor A, NELF-A, Wolf-Hirschhorn syndrome candidate 2 protein, NELFA, WHSC2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NELFA
Synonyms WHSC2
Function Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
Cellular Location Nucleus.
Tissue Location Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
Research Areas
Citations (0)

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Background

This gene is expressed ubiquitously with higher levels infetal than in adult tissues. It encodes a protein sharing 93%sequence identity with the mouse protein. Wolf-Hirschhorn syndrome(WHS) is a malformation syndrome associated with a hemizygousdeletion of the distal short arm of chromosome 4. This gene ismapped to the 165 kb WHS critical region, and may play a role inthe phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encodedprotein is found to be capable of reacting with HLA-A2-restrictedand tumor-specific cytotoxic T lymphocytes, suggesting a target foruse in specific immunotherapy for a large number of cancerpatients. This protein has also been shown to be a member of theNELF (negative elongation factor) protein complex that participatesin the regulation of RNA polymerase II transcription elongation.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Narita, T., et al. Mol. Cell 26(3):349-365(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Ping, Y.H., et al. J. Biol. Chem. 276(16):12951-12958(2001)

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$ 80.00
Cat# BP14802c
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