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WHSC2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H3P2 |
|---|---|
| Clone Names | 100430354 |
| Gene ID | 7469 |
|---|---|
| Other Names | Negative elongation factor A, NELF-A, Wolf-Hirschhorn syndrome candidate 2 protein, NELFA, WHSC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NELFA |
|---|---|
| Synonyms | WHSC2 |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P- TEFb kinase complex. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is expressed ubiquitously with higher levels infetal than in adult tissues. It encodes a protein sharing 93%sequence identity with the mouse protein. Wolf-Hirschhorn syndrome(WHS) is a malformation syndrome associated with a hemizygousdeletion of the distal short arm of chromosome 4. This gene ismapped to the 165 kb WHS critical region, and may play a role inthe phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encodedprotein is found to be capable of reacting with HLA-A2-restrictedand tumor-specific cytotoxic T lymphocytes, suggesting a target foruse in specific immunotherapy for a large number of cancerpatients. This protein has also been shown to be a member of theNELF (negative elongation factor) protein complex that participatesin the regulation of RNA polymerase II transcription elongation.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Narita, T., et al. Mol. Cell 26(3):349-365(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Ping, Y.H., et al. J. Biol. Chem. 276(16):12951-12958(2001)
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