|Other Names||Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Function||Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts|
|Tissue Location||Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene is one of the contiguous genes at 7q11.23commonly deleted in Williams syndrome, a multisystem developmentaldisorder. This gene consists of at least 14 exons, and itsalternative splicing generates 3 transcript variants, all encodingthe same protein.
Rieke, C., et al. Cell. Signal. 22(3):395-403(2010)Luo, X., et al. J. Clin. Endocrinol. Metab. 94(11):4533-4539(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Svojgr, K., et al. Immunol. Lett. 122(2):185-192(2009)Whittaker, G.C., et al. Blood 112(7):2869-2877(2008)
If you have any additional inquiries please email technical services at email@example.com.