|Other Names||Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Function||Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts|
|Tissue Location||Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).|
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This gene is one of the contiguous genes at 7q11.23commonly deleted in Williams syndrome, a multisystem developmentaldisorder. This gene consists of at least 14 exons, and itsalternative splicing generates 3 transcript variants, all encodingthe same protein.
Rieke, C., et al. Cell. Signal. 22(3):395-403(2010)Luo, X., et al. J. Clin. Endocrinol. Metab. 94(11):4533-4539(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)Svojgr, K., et al. Immunol. Lett. 122(2):185-192(2009)Whittaker, G.C., et al. Blood 112(7):2869-2877(2008)
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