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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   CPSF3 Antibody (Center) Blocking Peptide   

CPSF3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UKF6
Clone Names 100507013
Peptide ID 100507013
Additional Information
Gene ID 51692
Other Names Cleavage and polyadenylation specificity factor subunit 3, 3127-, Cleavage and polyadenylation specificity factor 73 kDa subunit, CPSF 73 kDa subunit, mRNA 3'-end-processing endonuclease CPSF-73, CPSF3, CPSF73
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPSF3
Synonyms CPSF73
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP- dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Most eukaryotic mRNA precursors (pre-mRNAs) undergoextensive maturational processing, including cleavage andpolyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunitof the cleavage and polyadenylation specificity factor (CPSF) andis the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al.,2006 [PubMed 17128255]).


Rozenblatt-Rosen, O., et al. Proc. Natl. Acad. Sci. U.S.A. 106(3):755-760(2009)Zhu, Z.H., et al. Oncogene 28(1):41-51(2009)Yang, X.C., et al. Mol. Cell. Biol. 29(1):31-42(2009)Kolev, N.G., et al. EMBO Rep. 9(10):1013-1018(2008)de la Vega, L., et al. J. Mol. Biol. 372(2):317-330(2007)

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$ 80.00
Cat# BP14804c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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