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FZD2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14332
Clone Names 100517173
Peptide ID 100517173
Additional Information
Gene ID 2535
Other Names Frizzled-2, Fz-2, hFz2, FzE2, FZD2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD2
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver
Research Areas
Citations (0)

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Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The expression of the FZD2 gene appears to bedevelopmentally regulated, with high levels of expression in fetalkidney and lung and in adult colon and ovary.


Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)Sato, A., et al. EMBO J. 29(1):41-54(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ollila, H.M., et al. Mol. Psychiatry 14(4):351-353(2009)Wang, H.X., et al. Mol. Hum. Reprod. 15(1):11-17(2009)

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$ 80.00
Cat# BP14806b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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