|Other Names||Frizzled-2, Fz-2, hFz2, FzE2, FZD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver|
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Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The expression of the FZD2 gene appears to bedevelopmentally regulated, with high levels of expression in fetalkidney and lung and in adult colon and ovary.
Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)Sato, A., et al. EMBO J. 29(1):41-54(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ollila, H.M., et al. Mol. Psychiatry 14(4):351-353(2009)Wang, H.X., et al. Mol. Hum. Reprod. 15(1):11-17(2009)
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