|Other Names||Receptor-type tyrosine-protein phosphatase gamma, Protein-tyrosine phosphatase gamma, R-PTP-gamma, PTPRG, PTPG|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Possesses tyrosine phosphatase activity.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Found in a variety of tissues.|
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The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP possesses an extracellularregion, a single transmembrane region, and two tandemintracytoplasmic catalytic domains, and thus represents areceptor-type PTP. The extracellular region of this PTP contains acarbonic anhydrase-like (CAH) domain, which is also found in theextracellular region of PTPRBETA/ZETA. This gene is located in achromosomal region that is frequently deleted in renal cellcarcinoma and lung carcinoma, thus is thought to be a candidatetumor suppressor gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Shu, S.T., et al. Anticancer Res. 30(6):1937-1946(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Bouyain, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(6):2443-2448(2010)Shi, J., et al. Mol. Psychiatry (2010) In press :
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