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PJA1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NG27
Clone Names 100525077
Peptide ID 100525077
Additional Information
Gene ID 64219
Other Names E3 ubiquitin-protein ligase Praja-1, Praja1, 632-, RING finger protein 70, PJA1, RNF70
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PJA1
Synonyms RNF70
Function Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.
Tissue Location Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.
Research Areas
Citations (0)

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Background

This gene encodes an enzyme that has E2-dependent E3ubiquitin-protein ligase activity. This enzyme belongs to a classof ubiquitin ligases that include a RING finger motif, and it caninteract with the E2 ubiquitin-conjugating enzyme UbcH5B. This geneis located in an area of chromosome X where several X-linked mentalretardation disorders have been associated, and it has also beenfound as part of a contiguous gene deletion associated withcraniofrontonasal syndrome, though a direct link to any disorderhas yet to be demonstrated. Alternative splicing results inmultiple transcript variants.

References

Wieland, I., et al. Clin. Genet. 72(6):506-516(2007)Saha, T., et al. Oncogene 25(5):693-705(2006)Mishra, L., et al. Cancer Biol. Ther. 4(7):694-699(2005)Sasaki, A., et al. J. Biol. Chem. 277(25):22541-22546(2002)Yu, P., et al. Genomics 79(6):869-874(2002)

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$ 80.00
Cat# BP14811a
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