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PJA1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NG27 |
|---|---|
| Clone Names | 100525077 |
| Gene ID | 64219 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase Praja-1, Praja1, 632-, RING finger protein 70, PJA1, RNF70 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PJA1 |
|---|---|
| Synonyms | RNF70 |
| Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. |
| Tissue Location | Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that has E2-dependent E3ubiquitin-protein ligase activity. This enzyme belongs to a classof ubiquitin ligases that include a RING finger motif, and it caninteract with the E2 ubiquitin-conjugating enzyme UbcH5B. This geneis located in an area of chromosome X where several X-linked mentalretardation disorders have been associated, and it has also beenfound as part of a contiguous gene deletion associated withcraniofrontonasal syndrome, though a direct link to any disorderhas yet to be demonstrated. Alternative splicing results inmultiple transcript variants.
References
Wieland, I., et al. Clin. Genet. 72(6):506-516(2007)Saha, T., et al. Oncogene 25(5):693-705(2006)Mishra, L., et al. Cancer Biol. Ther. 4(7):694-699(2005)Sasaki, A., et al. J. Biol. Chem. 277(25):22541-22546(2002)Yu, P., et al. Genomics 79(6):869-874(2002)
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