|Other Names||E3 ubiquitin-protein ligase Praja-1, Praja1, 632-, RING finger protein 70, PJA1, RNF70|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.|
|Tissue Location||Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.|
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This gene encodes an enzyme that has E2-dependent E3ubiquitin-protein ligase activity. This enzyme belongs to a classof ubiquitin ligases that include a RING finger motif, and it caninteract with the E2 ubiquitin-conjugating enzyme UbcH5B. This geneis located in an area of chromosome X where several X-linked mentalretardation disorders have been associated, and it has also beenfound as part of a contiguous gene deletion associated withcraniofrontonasal syndrome, though a direct link to any disorderhas yet to be demonstrated. Alternative splicing results inmultiple transcript variants.
Wieland, I., et al. Clin. Genet. 72(6):506-516(2007)Saha, T., et al. Oncogene 25(5):693-705(2006)Mishra, L., et al. Cancer Biol. Ther. 4(7):694-699(2005)Sasaki, A., et al. J. Biol. Chem. 277(25):22541-22546(2002)Yu, P., et al. Genomics 79(6):869-874(2002)
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