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TCEB1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15369 |
|---|---|
| Clone Names | 100525168 |
| Gene ID | 6921 |
|---|---|
| Other Names | Transcription elongation factor B polypeptide 1, Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, TCEB1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ELOC (HGNC:11617) |
|---|---|
| Function | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the protein elongin C, which is asubunit of the transcription factor B (SIII) complex. The SIIIcomplex is composed of elongins A/A2, B and C. It activateselongation by RNA polymerase II by suppressing transient pausing ofthe polymerase at many sites within transcription units. Elongin Afunctions as the transcriptionally active component of the SIIIcomplex, whereas elongins B and C are regulatory subunits. ElonginA2 is specifically expressed in the testis, and capable of forminga stable complex with elongins B and C. The von Hippel-Lindau tumorsuppressor protein binds to elongins B and C, and thereby inhibitstranscription elongation.
References
Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lievens, S., et al. J. Proteome Res. 8(2):877-886(2009)Jalava, S.E., et al. Int. J. Cancer 124(1):95-102(2009)Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)
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