|Other Names||C-X-C motif chemokine 11, Beta-R1, H174, Interferon gamma-inducible protein 9, IP-9, Interferon-inducible T-cell alpha chemoattractant, I-TAC, Small-inducible cytokine B11, CXCL11, ITAC, SCYB11, SCYB9B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ITAC, SCYB11, SCYB9B|
|Function||Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.|
|Tissue Location||High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine Also found in epidermal basal layer keratinocytes in skin disorders|
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Chemokines are a group of small (approximately 8 to 14kD), mostly basic, structurally related molecules that regulatecell trafficking of various types of leukocytes throughinteractions with a subset of 7-transmembrane, G protein-coupledreceptors. Chemokines also play fundamental roles in thedevelopment, homeostasis, and function of the immune system, andthey have effects on cells of the central nervous system as well ason endothelial cells involved in angiogenesis or angiostasis.Chemokines are divided into 2 major subfamilies, CXC and CC. Thisgene is a CXC member of the chemokine superfamily. Its encodedprotein induces a chemotactic response in activated T-cells and isthe dominant ligand for CXC receptor-3. The gene encoding thisprotein contains 4 exons and at least three polyadenylation signalswhich might reflect cell-specific regulation of expression.IFN-gamma is a potent inducer of transcription of this gene.
Rot, A. Front. Biosci. 15, 645-660 (2010) :Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)Kouroumalis, A., et al. J. Immunol. 175(8):5403-5411(2005)Booth, V., et al. Protein Sci. 13(8):2022-2028(2004)Colvin, R.A., et al. J. Biol. Chem. 279(29):30219-30227(2004)
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