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Mouse Ephb3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P54754
Clone Names 110316151
Peptide ID 110316151
Additional Information
Gene ID 13845
Other Names Ephrin type-B receptor 3, Developmental kinase 5, mDK-5, Tyrosine-protein kinase receptor SEK-4, Ephb3, Etk2, Mdk5, Sek4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ephb3
Synonyms Etk2, Mdk5, Sek4
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
Cellular Location Cell membrane; Single-pass type I membrane protein Cell projection, dendrite
Tissue Location Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level)
Research Areas
Citations (0)

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Ephb3 is a receptor for members of the ephrin-B family.

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$ 80.00
Cat# BP14819c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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