|Other Names||Polycystin-2, Autosomal dominant polycystic kidney disease type II protein, Polycystic kidney disease 2 protein, Polycystwin, R48321, PKD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).|
|Cellular Location||Cell projection, cilium membrane; Multi- pass membrane protein. Endoplasmic reticulum. Cell membrane. Note=Cell surface and cilium localization requires GANAB.|
|Tissue Location||Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.|
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This gene encodes a member of the polycystin proteinfamily. The encoded protein contains multiple transmembranedomains, and cytoplasmic N- and C-termini. The protein may be anintegral membrane protein involved in cell-cell/matrixinteractions. The encoded protein may function in renal tubulardevelopment, morphology, and function, and may modulateintracellular calcium homoeostasis and other signal transductionpathways. This protein interacts with polycystin 1 to producecation-permeable currents. Mutations in this gene have beenassociated with autosomal dominant polycystic kidney disease.
Duning, K., et al. J. Biol. Chem. 285(44):33584-33588(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Stewart, A.P., et al. Biophys. J. 99(3):790-797(2010)Petri, E.T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(20):9176-9181(2010)Steiner, T.S., et al. Cell. Immunol. 264(2):135-142(2010)
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