|Other Names||DNA ligase 1, DNA ligase I, Polydeoxyribonucleotide synthase [ATP] 1, LIG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.|
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Provided below are standard protocols that you may find useful for product applications.
LIG1 encodes DNA ligase I, with functions in DNAreplication and the base excision repair process. Mutations inLIG1 that lead to DNA ligase I deficiency result inimmunodeficiency and increased sensitivity to DNA-damaging agents.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Arora, M., et al. Leukemia 24(8):1470-1475(2010)Guillem, V.M., et al. Am. J. Hematol. 85(7):482-486(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
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