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LALBA Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00709 |
|---|---|
| Clone Names | 100507298 |
| Gene ID | 3906 |
|---|---|
| Other Names | Alpha-lactalbumin, Lactose synthase B protein, Lysozyme-like protein 7, LALBA, LYZL7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LALBA |
|---|---|
| Synonyms | LYZL7 |
| Function | Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins. |
| Cellular Location | Secreted. |
| Tissue Location | Mammary gland specific. Secreted in milk. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes alpha-lactalbumin, a principal proteinof milk. Alpha-lactalbumin forms the regulatory subunit of thelactose synthase (LS) heterodimer and beta1,4-galactosyltransferase (beta4Gal-T1) forms the catalyticcomponent. Together, these proteins enable LS to produce lactose bytransfering galactose moieties to glucose. As a monomer,alpha-lactalbumin strongly binds calcium and zinc ions and maypossess bactericidal or antitumor activity. A folding variant ofalpha-lactalbumin, called HAMLET, likely induces apoptosis in tumorand immature cells.
References
Tolin, S., et al. FEBS J. 277(1):163-173(2010)Rosner, H.I., et al. J. Mol. Biol. 394(2):351-362(2009)Wang, J., et al. J. Dairy Sci. 91(12):4466-4476(2008)Ramboarina, S., et al. J. Am. Chem. Soc. 130(46):15318-15326(2008)Morozova, O.B., et al. J Phys Chem B 109(12):5912-5918(2005)
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