|Other Names||Alpha-lactalbumin, Lactose synthase B protein, Lysozyme-like protein 7, LALBA, LYZL7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.|
|Tissue Location||Mammary gland specific. Secreted in milk.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes alpha-lactalbumin, a principal proteinof milk. Alpha-lactalbumin forms the regulatory subunit of thelactose synthase (LS) heterodimer and beta1,4-galactosyltransferase (beta4Gal-T1) forms the catalyticcomponent. Together, these proteins enable LS to produce lactose bytransfering galactose moieties to glucose. As a monomer,alpha-lactalbumin strongly binds calcium and zinc ions and maypossess bactericidal or antitumor activity. A folding variant ofalpha-lactalbumin, called HAMLET, likely induces apoptosis in tumorand immature cells.
Tolin, S., et al. FEBS J. 277(1):163-173(2010)Rosner, H.I., et al. J. Mol. Biol. 394(2):351-362(2009)Wang, J., et al. J. Dairy Sci. 91(12):4466-4476(2008)Ramboarina, S., et al. J. Am. Chem. Soc. 130(46):15318-15326(2008)Morozova, O.B., et al. J Phys Chem B 109(12):5912-5918(2005)
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