TCF12 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q99081 |
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Clone Names | 100507304 |
Gene ID | 6938 |
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Other Names | Transcription factor 12, TCF-12, Class B basic helix-loop-helix protein 20, bHLHb20, DNA-binding protein HTF4, E-box-binding protein, Transcription factor HTF-4, TCF12, BHLHB20, HEB, HTF4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TCF12 |
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Synonyms | BHLHB20, HEB, HTF4 |
Function | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis (PubMed:32620954). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the basichelix-loop-helix (bHLH) E-protein family that recognizes theconsensus binding site (E-box) CANNTG. This encoded protein isexpressed in many tissues, among them skeletal muscle, thymus, B-and T-cells, and may participate in regulating lineage-specificgene expression through the formation of heterodimers with otherbHLH E-proteins. Several alternatively spliced transcript variantsof this gene have been described, but the full-length nature ofsome of these variants has not been determined. [provided byRefSeq].
References
Schotte, R., et al. J. Immunol. 184(12):6670-6679(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Gardini, A., et al. PLoS Genet. 4 (11), E1000275 (2008) :Kumar, R., et al. J. Biol. Chem. 283(27):19026-19038(2008)
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