|Other Names||Transcription factor 12, TCF-12, Class B basic helix-loop-helix protein 20, bHLHb20, DNA-binding protein HTF4, E-box-binding protein, Transcription factor HTF-4, TCF12, BHLHB20, HEB, HTF4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHB20, HEB, HTF4|
|Function||Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').|
|Tissue Location||Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the basichelix-loop-helix (bHLH) E-protein family that recognizes theconsensus binding site (E-box) CANNTG. This encoded protein isexpressed in many tissues, among them skeletal muscle, thymus, B-and T-cells, and may participate in regulating lineage-specificgene expression through the formation of heterodimers with otherbHLH E-proteins. Several alternatively spliced transcript variantsof this gene have been described, but the full-length nature ofsome of these variants has not been determined. [provided byRefSeq].
Schotte, R., et al. J. Immunol. 184(12):6670-6679(2010)Rose, J. Phd, et al. Mol. Med. (2010) In press :Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :Gardini, A., et al. PLoS Genet. 4 (11), E1000275 (2008) :Kumar, R., et al. J. Biol. Chem. 283(27):19026-19038(2008)
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