|Other Names||Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, hCAP, SMC3, BAM, BMH, CSPG6, SMC3L1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BAM, BMH, CSPG6, SMC3L1|
|Function||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.|
|Cellular Location||Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser- 1083 is preferentially associated with unsynapsed chromosomal regions (By similarity).|
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This gene belongs to the SMC3 subfamily of SMC proteins.The encoded protein occurs in certain cell types as either anintracellular, nuclear protein or a secreted protein. The nuclearform, known as structural maintenance of chromosomes 3, is acomponent of the multimeric cohesin complex that holds togethersister chromatids during mitosis, enabling proper chromosomesegregation. Post-translational modification of the encoded proteinby the addition of chondroitin sulfate chains gives rise to thesecreted proteoglycan bamacan, an abundant basement membraneprotein.
Pie, J., et al. Am. J. Med. Genet. A 152A (4), 924-929 (2010) :Terret, M.E., et al. Nature 462(7270):231-234(2009)Revenkova, E., et al. Hum. Mol. Genet. 18(3):418-427(2009)Ridinger, H., et al. Exp. Mol. Pathol. 86(1):23-31(2009)Mohan, K.V., et al. J. Neurovirol. 15(3):229-237(2009)
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