|Other Names||Eukaryotic elongation factor 2 kinase, eEF-2 kinase, eEF-2K, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, Eef2k|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.|
|Tissue Location||Ubiquitously expressed. Particularly abundant in skeletal muscle and heart|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates eukaryotic elongation factor-2. Binds calmodulin (By similarity).
Khan, A.A., et al. Am. J. Pathol. 177(1):481-492(2010)Shen, Q., et al. Parkinsonism Relat. Disord. 15(7):525-531(2009)Py, B.F., et al. Autophagy 5(3):393-396(2009)Im, H.I., et al. PLoS ONE 4 (10), E7424 (2009) :Crawley, S.W., et al. Biochim. Biophys. Acta 1784(6):908-915(2008)
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