|Other Names||Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.|
|Tissue Location||Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung|
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Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Akerblom, B., et al. Mol. Cell. Endocrinol. 270 (1-2), 73-78 (2007) :Nishimura, M., et al. DNA Res. 11(5):315-323(2004)Sharov, A.A., et al. PLoS Biol. 1 (3), E74 (2003) :Cowen, M.S., et al. Alcohol. Clin. Exp. Res. 27(8):1213-1219(2003)Serfas, M.S., et al. Oncol. Res. 13 (6-10), 409-419 (2003) :
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