Mouse Grk1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9WVL4 |
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Clone Names | 110316173 |
Other Names | Rhodopsin kinase, RK, G protein-coupled receptor kinase 1, Grk1, Rhok |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Grk1 {ECO:0000312|MGI:MGI:1345146} |
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Synonyms | Rhok |
Function | Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:10097103, PubMed:10704496, PubMed:26427409). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (PubMed:10097103, PubMed:10704496). May play a role in the maintenance of the outer nuclear layer in the retina (PubMed:26427409). |
Cellular Location | Membrane {ECO:0000250|UniProtKB:P28327}; Lipid- anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment Note=Subcellular location is not affected by light or dark conditions |
Tissue Location | Expressed in the retina; primarily located in rod outer segments of retina photoreceptor cells (at protein level) (PubMed:11717351, PubMed:15961391, PubMed:21504899). Also detected in cone photoreceptor cells (at protein level) (PubMed:10704496) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates rhodopsin thereby initiating its deactivation.
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