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SCF (KITLG) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P21583
Clone Names 71213130
Peptide ID 71213130
Additional Information
Gene ID 4254
Other Names Kit ligand, Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand, Soluble KIT ligand, sKITLG, KITLG, MGF, SCF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1484c was selected from the Center region of human KITLG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MGF, SCF
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Soluble KIT ligand: Secreted.
Research Areas
Citations (0)

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KITLG is the ligand of the tyrosine-kinase receptor. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis.


Young,S.M., Cell. Signal. 19 (12), 2572-2581 (2007)Pick,M., Stem Cells 25 (9), 2206-2214 (2007)Yasuda,A., Dig. Dis. Sci. 52 (9), 2292-2300 (2007)

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$ 80.00
Cat# BP1484c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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