|Other Names||Ras-related protein Rap-1b, GTP-binding protein smg p21B, RAP1B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.|
|Cellular Location||Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol Presence of KRIT1 and CDH5 is required for its localization to the cell junction|
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Provided below are standard protocols that you may find useful for product applications.
RAP1B and RAP1A (MIM 179520) belong to a superfamily ofRAS (see MIM 190020)-like small GTP-binding proteins involved incell signaling.
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Malchinkhuu, E., et al. Mol. Biol. Cell 20(24):5156-5165(2009)Edreira, M.M., et al. J. Biol. Chem. 284(40):27480-27486(2009)Matsuse, M., et al. Endocr. J. 56(1):161-164(2009)Li, Y.H., et al. J. Biol. Chem. 283(48):33784-33792(2008)
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